Anal beads have a simple use, they are to be gently pulled out of the anus right at the time of climax. Just like all anal toys plenty of water-based lube should be used.
Timing is very important when using anal beads, and when using them with a partner communication is also critical. Always make sure your partner knows what he or she should be doing, whether it's adding more lube, pushing in another bead or, when it's time, right at climax, pulling them out.
Quick tip: when removing anal beads be sure to pull them straight out, not angled up or down.